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Antioxidative effects of statins Scarica

HMG CoA reductase inhibitiors (statins) 
have been shown to be effective lipid lowering agents
and are beneficial in the primary and secondary prevention
of coronary heart disease. However, the overall benefits
observed with statins appear to be greater than what might
be expected from changes in lipid levels alone and the positive
effects have only partially been reproduced with other
lipid lowering drugs, suggesting effects in addition to cholesterol
lowering. In experimental models, many of the cholesterol-
independent effects of statins are mediated by
inhibition of isoprenoids, which serve as lipid attachments
for intracellular signalling molecules such as small Rho
guanosine triphosphate-binding proteins, whose membrane
localization and function are dependent on isoprenylation.
This review summarizes the effects
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