Altered redox signaling contributes to CCM pathogenesis
Martedì 05 Settembre 2017 15:02
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Scientific Reports Telethon

A recent research work published in Scientific Reports and supported by the Telethon Foundation demonstrate that altered redox signaling is a major contributor to increased endothelial permeability in experimental models of CCM disease, thus confirming and extending previous reports suggesting that oxidative stress plays an important role in CCM pathogenesis and severity.


Scientific ReportsSci Rep. 2017 Aug 15;7(1):8296.

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.

Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF & Glading AJ.



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Ultimo aggiornamento Martedì 05 Settembre 2017 17:12