Cerebral Cavernous Malformations (CCM) - Methods and Protocols | The Book

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Cerebral Cavernous Malformations (CCM) - Methods and Protocols | Book
Editors: Lorenza Trabalzini, Federica Finetti and Saverio Francesco Retta
This volume of Methods in Molecular Biology is focused on the biomedical issue of Cerebral Cavernous Malformation (CCM) disease in a multidisciplinary perspective. Indeed, it ranges from the first discoveries of the CCM genes and subsequent characterizations of their physiological and pathological functions, to the last development of the diagnostic and therapeutic methodologies in the field, thus involving all the disciplines concerned (neurosurgery, neuroradiology, neurology, epidemiology, clinical and molecular genetics, molecular, cellular and developmental biology, proteomics, bioinformatics, etc.). Indeed, besides constituting a comprehensive collection of multidisciplinary experimental procedures used in the CCM field and answering the need for standardized protocols, this detailed volume brings together for the first time articles of many of the leading researchers who have contributed significantly to the advancement of scientific knowledge on clinical, genetic and molecular aspects of CCM disease, including epidemiologists, neuroradiologists, neurosurgeons, geneticists, and molecular, cellular and developmental biologists. This authoritative and practical book may therefore serve as a valuable resource for experienced researchers in distinct but complementary clinical and basic research disciplines, but also for future investigators and young students starting to study this complex disease and its pathophysiologic correlates.